fig4
From: Oxidative stress-mediated inflammation promotes the pathogenesis of amyotrophic lateral sclerosis
Figure 4. Serum and CSF levels of HNE in patients with sporadic ALS (sALS), familial ALS (fALS), non-ALS neurodegenerative diseases (ND) compared with normal controls (NC). Serum HNE levels in 75 patients with sALS (grey columns) were significantly increased compared to NCs (P < 0.0001, 10 fALS (P < 0.05), and 19 NDs (P < 0.001). CSF HNE levels (black columns) were significantly increased compared with serum HNE levels in sALS patients (P < 0.001). ***P < 0.0001, **P < 0.001, *P < 0.05, compared with sALS sera; ##P < 0.001, #P < 0.05, compared with sALS CSF (Modified from Figure 1, Ref. 37[37]). CSF: Cerebrospinal fluid; HNE: 4-hydroxynonenal.
